Symbol: Name: ID: |
ACVR1 activin A receptor, type I GFS:6194 |
Gene name: | ACVR1 |
Chromosome: | 2q23-q24 |
Previous Symbols: | ACVRLK2 |
Previous Names: | |
Aliases: | SKR1, ALK2, ACVR1A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:87911 | Rat Genome Database ID: | RGD:620200 |
HGNC ID: | HGNC:171 | RefSeq IDs: | NM_001105 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000115170 | |
VEGA IDs: | OTTHUMG00000131967 | UniProt ID: | Q04771 |
UCSC ID: | uc010fog.2 | OMIM ID: | 102576 |
Pubmed: | PMID8397373 | ||
CCDS IDs: | CCDSCCDS2206.1 |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008].
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
Products for ACVR1 gene
Catalog | Product Name | Application | Company |
GFS:E06194 | activin A receptor, type I; ELISA kit | ELISA | n/a |
GFS:A06194 | activin A receptor, type I; Anti | ANTIBODIES | n/a |
GFS:P06194 | activin A receptor, type I; Protien | Protien | n/a |