Symbol: Name: ID: |
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 GFS:2583 |
Gene name: | XRCC4 |
Chromosome: | 5q14.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | X-ray repair, complementing defective, repair in Chinese hamster, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333799 | Rat Genome Database ID: | RGD:1359573 |
HGNC ID: | HGNC:12831 | RefSeq IDs: | NM_003401 |
Entrez Gene ID: | 7518 | Ensembl Gene ID: | ENSG00000152422 |
VEGA IDs: | OTTHUMG00000131319 | UniProt ID: | Q13426 |
UCSC ID: | uc003kib.2 | OMIM ID: | 194363 |
Pubmed: | PMID1697445 PMID 7665175 | ||
CCDS IDs: | CCDSCCDS4058.1 CCDS CCDS4059.1 |
DNA repair protein XRCC4 is a protein that in humans is encoded by the XRCC4 gene.
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq].
Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends
Products for XRCC4 gene
Catalog | Product Name | Application | Company |
GFS:E02583 | X-ray repair complementing defective repair in Chinese hamster cells 4; ELISA kit | ELISA | n/a |
GFS:A02583 | X-ray repair complementing defective repair in Chinese hamster cells 4; Anti | ANTIBODIES | n/a |
GFS:P02583 | X-ray repair complementing defective repair in Chinese hamster cells 4; Protien | Protien | n/a |