Symbol: Name: ID: |
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 GFS:2579 |
Gene name: | XRCC1 |
Chromosome: | 19q13.2 |
Previous Symbols: | RCC |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99137 | Rat Genome Database ID: | RGD:619823 |
HGNC ID: | HGNC:12828 | RefSeq IDs: | NM_006297 |
Entrez Gene ID: | 7515 | Ensembl Gene ID: | ENSG00000073050 |
VEGA IDs: | UniProt ID: | P18887 | |
UCSC ID: | uc002owt.2 | OMIM ID: | 194360 |
Pubmed: | PMID2247054 | ||
CCDS IDs: | CCDSCCDS12624.1 |
XRCC1 is a DNA repair protein.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Products for XRCC1 gene
Catalog | Product Name | Application | Company |
GFS:E02579 | X-ray repair complementing defective repair in Chinese hamster cells 1; ELISA kit | ELISA | n/a |
GFS:A02579 | X-ray repair complementing defective repair in Chinese hamster cells 1; Anti | ANTIBODIES | n/a |
GFS:P02579 | X-ray repair complementing defective repair in Chinese hamster cells 1; Protien | Protien | n/a |