Symbol: Name: ID: |
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 GFS:2582 |
Gene name: | XRCC3 |
Chromosome: | 14q32.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | RAD51-like |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921585 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12830 | RefSeq IDs: | NM_001100118 |
Entrez Gene ID: | 7517 | Ensembl Gene ID: | ENSG00000126215 |
VEGA IDs: | UniProt ID: | O43542 | |
UCSC ID: | uc001ynz.3 | OMIM ID: | 600675 |
Pubmed: | PMID7603995 | ||
CCDS IDs: | CCDSCCDS9984.1 |
DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene.
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
Products for XRCC3 gene
Catalog | Product Name | Application | Company |
GFS:E02582 | X-ray repair complementing defective repair in Chinese hamster cells 3; ELISA kit | ELISA | n/a |
GFS:A02582 | X-ray repair complementing defective repair in Chinese hamster cells 3; Anti | ANTIBODIES | n/a |
GFS:P02582 | X-ray repair complementing defective repair in Chinese hamster cells 3; Protien | Protien | n/a |