Symbol: Name: ID: |
TRAF3IP2 TRAF3 interacting protein 2 GFS:3016 |
Gene name: | TRAF3IP2 |
Chromosome: | 6q21 |
Previous Symbols: | C6orf4, C6orf5, C6orf6, C6orf2 |
Previous Names: | chromosome 6 open reading frame 5, "chromosome 6 open reading frame 2" |
Aliases: | DKFZP586G0522, ACT1, CIKS |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2143599 | Rat Genome Database ID: | RGD:1593240 |
HGNC ID: | HGNC:1343 | RefSeq IDs: | NM_001164281 |
Entrez Gene ID: | 10758 | Ensembl Gene ID: | ENSG00000056972 |
VEGA IDs: | OTTHUMG00000015379 | UniProt ID: | O43734 |
UCSC ID: | uc003pvf.2 | OMIM ID: | 607043 |
Pubmed: | PMID10962033 PMID 10962024 | ||
CCDS IDs: | CCDSCCDS5093.1 |
Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq].
Function: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
Products for TRAF3IP2 gene
Catalog | Product Name | Application | Company |
GFS:E03016 | TRAF3 interacting protein 2; ELISA kit | ELISA | n/a |
GFS:A03016 | TRAF3 interacting protein 2; Anti | ANTIBODIES | n/a |
GFS:P03016 | TRAF3 interacting protein 2; Protien | Protien | n/a |