Symbol: Name: ID: |
TRAF1 TNF receptor-associated factor 1 GFS:1828 |
Gene name: | TRAF1 |
Chromosome: | 9q33-q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | EBI6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101836 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12031 | RefSeq IDs: | NM_001190945 |
Entrez Gene ID: | 7185 | Ensembl Gene ID: | ENSG00000056558 |
VEGA IDs: | OTTHUMG00000020578 | UniProt ID: | Q13077 |
UCSC ID: | uc004bku.1 | OMIM ID: | 601711 |
Pubmed: | PMID8069916 | ||
CCDS IDs: | CCDSCCDS6825.1 |
TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Products for TRAF1 gene
Catalog | Product Name | Application | Company |
GFS:E01828 | TNF receptor-associated factor 1; ELISA kit | ELISA | n/a |
GFS:A01828 | TNF receptor-associated factor 1; Anti | ANTIBODIES | n/a |
GFS:P01828 | TNF receptor-associated factor 1; Protien | Protien | n/a |