Symbol: Name: ID: |
TRAF3 TNF receptor-associated factor 3 GFS:1830 |
Gene name: | TRAF3 |
Chromosome: | 14q32.32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CAP-1, CD40bp, CRAF1, LAP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108041 | Rat Genome Database ID: | RGD:1304633 |
HGNC ID: | HGNC:12033 | RefSeq IDs: | NM_001199427 |
Entrez Gene ID: | 7187 | Ensembl Gene ID: | ENSG00000131323 |
VEGA IDs: | UniProt ID: | Q13114 | |
UCSC ID: | uc001ymd.1 | OMIM ID: | 601896 |
Pubmed: | PMID7530216 PMID 7859281 | ||
CCDS IDs: | CCDSCCDS9975.1 CCDS CCDS9976.1 |
TNF receptor-associated factor 3 is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq].
Products for TRAF3 gene
Catalog | Product Name | Application | Company |
GFS:E01830 | TNF receptor-associated factor 3; ELISA kit | ELISA | n/a |
GFS:A01830 | TNF receptor-associated factor 3; Anti | ANTIBODIES | n/a |
GFS:P01830 | TNF receptor-associated factor 3; Protien | Protien | n/a |