Symbol: Name: ID: |
TEAD4 TEA domain family member 4 GFS:1535 |
Gene name: | TEAD4 |
Chromosome: | 12p13.3-p13.2 |
Previous Symbols: | TCF13L1 |
Previous Names: | |
Aliases: | TEF-3, TEFR-1, EFTR-2, RTEF-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106907 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11717 | RefSeq IDs: | NM_003213 |
Entrez Gene ID: | 7004 | Ensembl Gene ID: | ENSG00000197905 |
VEGA IDs: | UniProt ID: | Q15561 | |
UCSC ID: | uc010sej.1 | OMIM ID: | 601714 |
Pubmed: | PMID9889009 PMID 8921372 | ||
CCDS IDs: | CCDSCCDS31729.1 CCDS CCDS31730.1 CCDS CCDS41737.1 |
Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene. This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq].
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Products for TEAD4 gene
Catalog | Product Name | Application | Company |
GFS:E01535 | TEA domain family member 4; ELISA kit | ELISA | n/a |
GFS:A01535 | TEA domain family member 4; Anti | ANTIBODIES | n/a |
GFS:P01535 | TEA domain family member 4; Protien | Protien | n/a |