Symbol: Name: ID: |
TEAD3 TEA domain family member 3 GFS:1534 |
Gene name: | TEAD3 |
Chromosome: | 6p21.2 |
Previous Symbols: | TEAD5 |
Previous Names: | |
Aliases: | TEF-5, ETFR-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109241 | Rat Genome Database ID: | RGD:1311583 |
HGNC ID: | HGNC:11716 | RefSeq IDs: | NM_003214 |
Entrez Gene ID: | 7005 | Ensembl Gene ID: | ENSG00000007866 |
VEGA IDs: | OTTHUMG00000014571 | UniProt ID: | Q99594 |
UCSC ID: | uc003oku.3 | OMIM ID: | 603170 |
Pubmed: | PMID9889009 PMID 9148898 | ||
CCDS IDs: | CCDSCCDS47414.1 |
Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene. This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq].
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Products for TEAD3 gene
Catalog | Product Name | Application | Company |
GFS:E01534 | TEA domain family member 3; ELISA kit | ELISA | n/a |
GFS:A01534 | TEA domain family member 3; Anti | ANTIBODIES | n/a |
GFS:P01534 | TEA domain family member 3; Protien | Protien | n/a |