Symbol: Name: ID: |
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) GFS:1532 |
Gene name: | TEAD1 |
Chromosome: | 11p15.4 |
Previous Symbols: | TCF13, AA |
Previous Names: | atrophia areata, peripapillary chorioretinal degeneration |
Aliases: | TEF-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101876 | Rat Genome Database ID: | RGD:1549742 |
HGNC ID: | HGNC:11714 | RefSeq IDs: | NM_021961 |
Entrez Gene ID: | 7003 | Ensembl Gene ID: | ENSG00000187079 |
VEGA IDs: | UniProt ID: | P28347 | |
UCSC ID: | uc001mkj.3 | OMIM ID: | 189967 |
Pubmed: | PMID1851669 PMID 9889009 PMID 15016762 | ||
CCDS IDs: | CCDSCCDS7810.1 |
Transcriptional enhancer factor TEF-1 is a protein that in humans is encoded by the TEAD1 gene. This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Products for TEAD1 gene
Catalog | Product Name | Application | Company |
GFS:E01532 | TEA domain family member 1 (SV40 transcriptional enhancer factor); ELISA kit | ELISA | n/a |
GFS:A01532 | TEA domain family member 1 (SV40 transcriptional enhancer factor); Anti | ANTIBODIES | n/a |
GFS:P01532 | TEA domain family member 1 (SV40 transcriptional enhancer factor); Protien | Protien | n/a |