| Symbol: Name: ID: |
TEAD2 TEA domain family member 2 GFS:1533 |
| Gene name: | TEAD2 |
| Chromosome: | 19q13.3 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | TEF-4, ETF, TEF4 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:104904 | Rat Genome Database ID: | RGD:1593252 |
| HGNC ID: | HGNC:11715 | RefSeq IDs: | NM_003598 |
| Entrez Gene ID: | 8463 | Ensembl Gene ID: | ENSG00000074219 |
| VEGA IDs: | UniProt ID: | Q15562 | |
| UCSC ID: | uc002pnj.2 | OMIM ID: | 601729 |
| Pubmed: | PMID9889009 PMID 8702974 | ||
| CCDS IDs: | CCDSCCDS12761.1 | ||
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Products for TEAD2 gene
| Catalog | Product Name | Application | Company |
| GFS:E01533 | TEA domain family member 2; ELISA kit | ELISA | n/a |
| GFS:A01533 | TEA domain family member 2; Anti | ANTIBODIES | n/a |
| GFS:P01533 | TEA domain family member 2; Protien | Protien | n/a |