Symbol: Name: ID: |
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 GFS:6747 |
Gene name: | ST6GALNAC4 |
Chromosome: | 9q34 |
Previous Symbols: | SIAT7D |
Previous Names: | sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) |
Aliases: | ST6GALNACIV, SIAT3C |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341894 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17846 | RefSeq IDs: | NM_175039 |
Entrez Gene ID: | 27090 | Ensembl Gene ID: | ENSG00000136840 |
VEGA IDs: | OTTHUMG00000020724 | UniProt ID: | Q9H4F1 |
UCSC ID: | uc004bss.2 | OMIM ID: | 606378 |
Pubmed: | PMID10207017 PMID 11062056 | ||
CCDS IDs: | CCDSCCDS6883.1 |
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enyzme that in humans is encoded by the ST6GALNAC4 gene.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).
Products for ST6GALNAC4 gene
Catalog | Product Name | Application | Company |
GFS:E06747 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ELISA kit | ELISA | n/a |
GFS:A06747 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Anti | ANTIBODIES | n/a |
GFS:P06747 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Protien | Protien | n/a |