Symbol: Name: ID: |
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 GFS:4787 |
Gene name: | ARHGEF15 |
Chromosome: | 17p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0915, Vsm-RhoGEF, ARGEF15, FLJ13791, MGC44868 |
Name Aliases: | Rho guanine exchange factor (GEF) 15 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3045246 | Rat Genome Database ID: | RGD:1306961 |
HGNC ID: | HGNC:15590 | RefSeq IDs: | NM_025014 |
Entrez Gene ID: | 22899 | Ensembl Gene ID: | ENSG00000198844 |
VEGA IDs: | OTTHUMG00000108187 | UniProt ID: | O94989 |
UCSC ID: | uc002glc.2 | OMIM ID: | 608504 |
Pubmed: | PMID10048485 | ||
CCDS IDs: | CCDSCCDS11139.1 |
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010].
Function: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
Products for ARHGEF15 gene
Catalog | Product Name | Application | Company |
GFS:E04787 | Rho guanine nucleotide exchange factor (GEF) 15; ELISA kit | ELISA | n/a |
GFS:A04787 | Rho guanine nucleotide exchange factor (GEF) 15; Anti | ANTIBODIES | n/a |
GFS:P04787 | Rho guanine nucleotide exchange factor (GEF) 15; Protien | Protien | n/a |