Symbol: Name: ID: |
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 GFS:3576 |
Gene name: | ARHGEF12 |
Chromosome: | 11q23.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0382, LARG |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916882 | Rat Genome Database ID: | RGD:1305111 |
HGNC ID: | HGNC:14193 | RefSeq IDs: | NM_001198665 |
Entrez Gene ID: | 23365 | Ensembl Gene ID: | ENSG00000196914 |
VEGA IDs: | UniProt ID: | Q9NZN5 | |
UCSC ID: | uc001pxl.1 | OMIM ID: | 604763 |
Pubmed: | PMID10681437 PMID 9205841 | ||
CCDS IDs: | CCDSCCDS41727.1 |
Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Products for ARHGEF12 gene
Catalog | Product Name | Application | Company |
GFS:E03576 | Rho guanine nucleotide exchange factor (GEF) 12; ELISA kit | ELISA | n/a |
GFS:A03576 | Rho guanine nucleotide exchange factor (GEF) 12; Anti | ANTIBODIES | n/a |
GFS:P03576 | Rho guanine nucleotide exchange factor (GEF) 12; Protien | Protien | n/a |