Symbol: Name: ID: |
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 GFS:6185 |
Gene name: | ARHGEF18 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | rho/rac guanine nucleotide exchange factor (GEF) 18 |
Aliases: | P114-RhoGEF, KIAA0521, MGC15913 |
Name Aliases: | Rho-specific guanine nucleotide exchange factor p114 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2142567 | Rat Genome Database ID: | RGD:1311448 |
HGNC ID: | HGNC:17090 | RefSeq IDs: | NM_001130955 |
Entrez Gene ID: | 23370 | Ensembl Gene ID: | ENSG00000104880 |
VEGA IDs: | UniProt ID: | Q6ZSZ5 | |
UCSC ID: | uc002mgi.2 | OMIM ID: | |
Pubmed: | PMID9628581 PMID 11318610 | ||
CCDS IDs: | CCDSCCDS12177.1 CCDS CCDS45946.1 |
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.
Products for ARHGEF18 gene
Catalog | Product Name | Application | Company |
GFS:E06185 | Rho/Rac guanine nucleotide exchange factor (GEF) 18; ELISA kit | ELISA | n/a |
GFS:A06185 | Rho/Rac guanine nucleotide exchange factor (GEF) 18; Anti | ANTIBODIES | n/a |
GFS:P06185 | Rho/Rac guanine nucleotide exchange factor (GEF) 18; Protien | Protien | n/a |