Symbol: Name: ID: |
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 GFS:3887 |
Gene name: | ARHGEF11 |
Chromosome: | 1q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0380, GTRAP48, PDZ-RHOGEF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2441869 | Rat Genome Database ID: | RGD:619705 |
HGNC ID: | HGNC:14580 | RefSeq IDs: | NM_014784 |
Entrez Gene ID: | 9826 | Ensembl Gene ID: | ENSG00000132694 |
VEGA IDs: | OTTHUMG00000041292 | UniProt ID: | O15085 |
UCSC ID: | uc001fqn.2 | OMIM ID: | 605708 |
Pubmed: | PMID10526156 PMID 9205841 | ||
CCDS IDs: | CCDSCCDS1162.1 CCDS CCDS1163.1 |
Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Products for ARHGEF11 gene
Catalog | Product Name | Application | Company |
GFS:E03887 | Rho guanine nucleotide exchange factor (GEF) 11; ELISA kit | ELISA | n/a |
GFS:A03887 | Rho guanine nucleotide exchange factor (GEF) 11; Anti | ANTIBODIES | n/a |
GFS:P03887 | Rho guanine nucleotide exchange factor (GEF) 11; Protien | Protien | n/a |