Symbol: Name: ID: |
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) GFS:6254 |
Gene name: | RAB3GAP2 |
Chromosome: | 1p36.13-p35.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RAB3-GAP150, KIAA0839, DKFZP434D245 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916043 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17168 | RefSeq IDs: | NM_012414 |
Entrez Gene ID: | 25782 | Ensembl Gene ID: | ENSG00000118873 |
VEGA IDs: | OTTHUMG00000037139 | UniProt ID: | Q9H2M9 |
UCSC ID: | uc010puk.1 | OMIM ID: | 609275 |
Pubmed: | PMID10048485 PMID 15696165 | ||
CCDS IDs: | CCDSCCDS31028.1 |
Rab3 GTPase-activating protein non-catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP2 gene.
The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009].
Function: Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Products for RAB3GAP2 gene
Catalog | Product Name | Application | Company |
GFS:E06254 | RAB3 GTPase activating protein subunit 2 (non-catalytic); ELISA kit | ELISA | n/a |
GFS:A06254 | RAB3 GTPase activating protein subunit 2 (non-catalytic); Anti | ANTIBODIES | n/a |
GFS:P06254 | RAB3 GTPase activating protein subunit 2 (non-catalytic); Protien | Protien | n/a |