Symbol: Name: ID: |
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) GFS:6157 |
Gene name: | RAB3GAP1 |
Chromosome: | 2q21.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RAB3GAP, KIAA0066, RAB3GAP130, WARBM1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2445001 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17063 | RefSeq IDs: | NM_001172435 |
Entrez Gene ID: | 22930 | Ensembl Gene ID: | ENSG00000115839 |
VEGA IDs: | OTTHUMG00000154889 | UniProt ID: | Q15042 |
UCSC ID: | uc002tuj.2 | OMIM ID: | 602536 |
Pubmed: | PMID9030515 PMID 15696165 | ||
CCDS IDs: | CCDSCCDS33294.1 |
Rab3 GTPase-activating protein catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP1 gene.
This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].
Function: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Products for RAB3GAP1 gene
Catalog | Product Name | Application | Company |
GFS:E06157 | RAB3 GTPase activating protein subunit 1 (catalytic); ELISA kit | ELISA | n/a |
GFS:A06157 | RAB3 GTPase activating protein subunit 1 (catalytic); Anti | ANTIBODIES | n/a |
GFS:P06157 | RAB3 GTPase activating protein subunit 1 (catalytic); Protien | Protien | n/a |