| Symbol: Name: ID: |
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 GFS:6616 |
| Gene name: | RABGEF1 |
| Chromosome: | 7q11.21 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | rabex-5, RABEX5 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1929459 | Rat Genome Database ID: | RGD:1307295 |
| HGNC ID: | HGNC:17676 | RefSeq IDs: | NM_014504 |
| Entrez Gene ID: | 27342 | Ensembl Gene ID: | ENSG00000154710 |
| VEGA IDs: | OTTHUMG00000129547 | UniProt ID: | Q9UJ41 |
| UCSC ID: | uc003tvh.2 | OMIM ID: | 609700 |
| Pubmed: | PMID12505986 PMID 11098082 | ||
| CCDS IDs: | CCDSCCDS5535.1 | ||
Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene.
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).
Products for RABGEF1 gene
| Catalog | Product Name | Application | Company |
| GFS:E06616 | RAB guanine nucleotide exchange factor (GEF) 1; ELISA kit | ELISA | n/a |
| GFS:A06616 | RAB guanine nucleotide exchange factor (GEF) 1; Anti | ANTIBODIES | n/a |
| GFS:P06616 | RAB guanine nucleotide exchange factor (GEF) 1; Protien | Protien | n/a |
