Symbol: Name: ID: |
KLF11 Kruppel-like factor 11 GFS:1627 |
Gene name: | KLF11 |
Chromosome: | 2p25 |
Previous Symbols: | TIEG2 |
Previous Names: | TGFB inducible early growth response 2 |
Aliases: | Tieg3, MODY7 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2653368 | Rat Genome Database ID: | RGD:1306646 |
HGNC ID: | HGNC:11811 | RefSeq IDs: | NM_001177716 |
Entrez Gene ID: | 8462 | Ensembl Gene ID: | ENSG00000172059 |
VEGA IDs: | OTTHUMG00000119004 | UniProt ID: | O14901 |
UCSC ID: | uc002raf.1 | OMIM ID: | 603301 |
Pubmed: | PMID9748269 PMID 11087666 | ||
CCDS IDs: | CCDSCCDS1668.1 |
Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene. The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
Products for KLF11 gene
Catalog | Product Name | Application | Company |
GFS:E01627 | Kruppel-like factor 11; ELISA kit | ELISA | n/a |
GFS:A01627 | Kruppel-like factor 11; Anti | ANTIBODIES | n/a |
GFS:P01627 | Kruppel-like factor 11; Protien | Protien | n/a |