Symbol: Name: ID: |
FBXW8 F-box and WD repeat domain containing 8 GFS:3140 |
Gene name: | FBXW8 |
Chromosome: | 12q24.23 |
Previous Symbols: | FBXO29 |
Previous Names: | F-box only protein 29, "F-box and WD-40 domain protein 8" |
Aliases: | FBX29, FBW6, FBW8 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1923041 | Rat Genome Database ID: | RGD:1306032 |
HGNC ID: | HGNC:13597 | RefSeq IDs: | NM_012174 |
Entrez Gene ID: | 26259 | Ensembl Gene ID: | ENSG00000174989 |
VEGA IDs: | UniProt ID: | Q8N3Y1 | |
UCSC ID: | uc001twg.1 | OMIM ID: | 609073 |
Pubmed: | PMID10531035 PMID 10531037 | ||
CCDS IDs: | CCDSCCDS9182.1 CCDS CCDS44988.1 |
F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Function: Substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Products for FBXW8 gene
Catalog | Product Name | Application | Company |
GFS:E03140 | F-box and WD repeat domain containing 8; ELISA kit | ELISA | n/a |
GFS:A03140 | F-box and WD repeat domain containing 8; Anti | ANTIBODIES | n/a |
GFS:P03140 | F-box and WD repeat domain containing 8; Protien | Protien | n/a |