| Symbol: Name: ID: |
FBXW10 F-box and WD repeat domain containing 10 GFS:1914 |
| Gene name: | FBXW10 |
| Chromosome: | 17p11 |
| Previous Symbols: | C17orf1, C17orf1A |
| Previous Names: | chromosome 17 open reading frame 1A, "F-box and WD-40 domain protein 10" |
| Aliases: | SM2SH2, HREP, Fbw10 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:3052463 | Rat Genome Database ID: | RGD:1563889 |
| HGNC ID: | HGNC:1211 | RefSeq IDs: | NM_031456 |
| Entrez Gene ID: | 10517 | Ensembl Gene ID: | ENSG00000171931 |
| VEGA IDs: | OTTHUMG00000059048 | UniProt ID: | Q5XX13 |
| UCSC ID: | uc002guj.2 | OMIM ID: | 611679 |
| Pubmed: | PMID9787083 PMID 7586531 | ||
| CCDS IDs: | CCDSCCDS11199.2 | ||
F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
Products for FBXW10 gene
| Catalog | Product Name | Application | Company |
| GFS:E01914 | F-box and WD repeat domain containing 10; ELISA kit | ELISA | n/a |
| GFS:A01914 | F-box and WD repeat domain containing 10; Anti | ANTIBODIES | n/a |
| GFS:P01914 | F-box and WD repeat domain containing 10; Protien | Protien | n/a |
