Symbol: Name: ID: |
FBXW7 F-box and WD repeat domain containing 7 GFS:5809 |
Gene name: | FBXW7 |
Chromosome: | 4q31.23 |
Previous Symbols: | |
Previous Names: | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) |
Aliases: | AGO, FLJ11071, SEL-10, SEL10, FBW7, FBX30, CDC4, FBXW6 |
Name Aliases: | archipelago homolog (Drosophila) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354695 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16712 | RefSeq IDs: | NM_001013415 |
Entrez Gene ID: | 55294 | Ensembl Gene ID: | ENSG00000109670 |
VEGA IDs: | UniProt ID: | Q969H0 | |
UCSC ID: | uc003ims.2 | OMIM ID: | 606278 |
Pubmed: | PMID10531037 PMID 11425854 | ||
CCDS IDs: | CCDSCCDS3777.1 CCDS CCDS3778.1 CCDS CCDS34078.1 |
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Products for FBXW7 gene
Catalog | Product Name | Application | Company |
GFS:E05809 | F-box and WD repeat domain containing 7; ELISA kit | ELISA | n/a |
GFS:A05809 | F-box and WD repeat domain containing 7; Anti | ANTIBODIES | n/a |
GFS:P05809 | F-box and WD repeat domain containing 7; Protien | Protien | n/a |