Symbol: Name: ID: |
CELF6 CUGBP, Elav-like family member 6 GFS:3485 |
Gene name: | CELF6 |
Chromosome: | 15q24 |
Previous Symbols: | BRUNOL6 |
Previous Names: | Bruno (Drosophila) -like 6, RNA binding protein, "bruno-like 6, RNA binding protein (Drosophila)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1923433 | Rat Genome Database ID: | RGD:1310451 |
HGNC ID: | HGNC:14059 | RefSeq IDs: | NM_001172684 |
Entrez Gene ID: | 60677 | Ensembl Gene ID: | ENSG00000140488 |
VEGA IDs: | OTTHUMG00000133444 | UniProt ID: | Q96J87 |
UCSC ID: | uc002auh.2 | OMIM ID: | 612681 |
Pubmed: | PMID10893231 | ||
CCDS IDs: | CCDSCCDS10242.1 |
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.
Products for CELF6 gene
Catalog | Product Name | Application | Company |
GFS:E03485 | CUGBP, Elav-like family member 6; ELISA kit | ELISA | n/a |
GFS:A03485 | CUGBP, Elav-like family member 6; Anti | ANTIBODIES | n/a |
GFS:P03485 | CUGBP, Elav-like family member 6; Protien | Protien | n/a |