Symbol: Name: ID: |
CELF4 CUGBP, Elav-like family member 4 GFS:3449 |
Gene name: | CELF4 |
Chromosome: | 18q12 |
Previous Symbols: | BRUNOL4 |
Previous Names: | Bruno (Drosophila) -like 4, RNA binding protein, "bruno-like 4, RNA binding protein (Drosophila)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1932407 | Rat Genome Database ID: | RGD:1307630 |
HGNC ID: | HGNC:14015 | RefSeq IDs: | NM_001025087 |
Entrez Gene ID: | 56853 | Ensembl Gene ID: | ENSG00000101489 |
VEGA IDs: | UniProt ID: | Q9BZC1 | |
UCSC ID: | uc002lae.2 | OMIM ID: | 612679 |
Pubmed: | PMID10893231 | ||
CCDS IDs: | CCDSCCDS32818.1 CCDS CCDS45856.1 CCDS CCDS45857.1 CCDS CCDS45858.1 |
CUG-BP- and ETR-3-like factor 4 is a protein that in humans is encoded by the BRUNOL4 gene.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Products for CELF4 gene
Catalog | Product Name | Application | Company |
GFS:E03449 | CUGBP, Elav-like family member 4; ELISA kit | ELISA | n/a |
GFS:A03449 | CUGBP, Elav-like family member 4; Anti | ANTIBODIES | n/a |
GFS:P03449 | CUGBP, Elav-like family member 4; Protien | Protien | n/a |