Symbol: Name: ID: |
CELF3 CUGBP, Elav-like family member 3 GFS:1773 |
Gene name: | CELF3 |
Chromosome: | 1q21 |
Previous Symbols: | TNRC4 |
Previous Names: | trinucleotide repeat containing 4 |
Aliases: | CAGH4, BRUNOL1, ERDA4, MGC57297 |
Name Aliases: | expanded repeat domain, CAG/CTG 4, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926034 | Rat Genome Database ID: | RGD:1563168 |
HGNC ID: | HGNC:11967 | RefSeq IDs: | NM_001172648 |
Entrez Gene ID: | 11189 | Ensembl Gene ID: | ENSG00000159409 |
VEGA IDs: | OTTHUMG00000013064 | UniProt ID: | Q5SZQ8 |
UCSC ID: | uc001eys.1 | OMIM ID: | 612678 |
Pubmed: | PMID9225980 | ||
CCDS IDs: | CCDSCCDS1002.1 |
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq].
Function: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Products for CELF3 gene
Catalog | Product Name | Application | Company |
GFS:E01773 | CUGBP, Elav-like family member 3; ELISA kit | ELISA | n/a |
GFS:A01773 | CUGBP, Elav-like family member 3; Anti | ANTIBODIES | n/a |
GFS:P01773 | CUGBP, Elav-like family member 3; Protien | Protien | n/a |