Symbol: Name: ID: |
CELF5 CUGBP, Elav-like family member 5 GFS:3484 |
Gene name: | CELF5 |
Chromosome: | 19p13 |
Previous Symbols: | BRUNOL5 |
Previous Names: | Bruno (Drosophila) -like 5, RNA binding protein, "bruno-like 5, RNA binding protein (Drosophila)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442333 | Rat Genome Database ID: | RGD:1565016 |
HGNC ID: | HGNC:14058 | RefSeq IDs: | NM_001172673 |
Entrez Gene ID: | 60680 | Ensembl Gene ID: | ENSG00000161082 |
VEGA IDs: | UniProt ID: | Q8N6W0 | |
UCSC ID: | uc002lxm.2 | OMIM ID: | 612680 |
Pubmed: | PMID10893231 | ||
CCDS IDs: | CCDSCCDS12106.1 |
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010].
Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Products for CELF5 gene
Catalog | Product Name | Application | Company |
GFS:E03484 | CUGBP, Elav-like family member 5; ELISA kit | ELISA | n/a |
GFS:A03484 | CUGBP, Elav-like family member 5; Anti | ANTIBODIES | n/a |
GFS:P03484 | CUGBP, Elav-like family member 5; Protien | Protien | n/a |