Symbol: Name: ID: |
CLEC7A C-type lectin domain family 7, member A GFS:3871 |
Gene name: | CLEC7A |
Chromosome: | 12p13.2-p12.3 |
Previous Symbols: | CLECSF12 |
Previous Names: | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 |
Aliases: | dectin-1, hDectin-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1861431 | Rat Genome Database ID: | RGD:1565140 |
HGNC ID: | HGNC:14558 | RefSeq IDs: | NM_022570 |
Entrez Gene ID: | 64581 | Ensembl Gene ID: | ENSG00000172243 |
VEGA IDs: | OTTHUMG00000133597 | UniProt ID: | Q9BXN2 |
UCSC ID: | uc001qxg.2 | OMIM ID: | 606264 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8613.1 CCDS CCDS8614.1 CCDS CCDS8617.1 CCDS CCDS41753.1 CCDS CCDS41754.1 |
C-type lectin domain family 7 member A is a protein that in humans is encoded by the CLEC7A gene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).
Products for CLEC7A gene
Catalog | Product Name | Application | Company |
GFS:E03871 | C-type lectin domain family 7, member A; ELISA kit | ELISA | n/a |
GFS:A03871 | C-type lectin domain family 7, member A; Anti | ANTIBODIES | n/a |
GFS:P03871 | C-type lectin domain family 7, member A; Protien | Protien | n/a |