Symbol: Name: ID: |
CLEC4C C-type lectin domain family 4, member C GFS:2906 |
Gene name: | CLEC4C |
Chromosome: | 12p13.2-p12.3 |
Previous Symbols: | CLECSF11, CLECSF7 |
Previous Names: | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 7 |
Aliases: | HECL, DLEC, BDCA2, CD303 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3588267 | Rat Genome Database ID: | RGD:1359354 |
HGNC ID: | HGNC:13258 | RefSeq IDs: | NM_130441 |
Entrez Gene ID: | 170482 | Ensembl Gene ID: | ENSG00000198178 |
VEGA IDs: | UniProt ID: | Q8WTT0 | |
UCSC ID: | uc001qth.1 | OMIM ID: | 606677 |
Pubmed: | PMID11031109 PMID 11536172 | ||
CCDS IDs: | CCDSCCDS8583.1 CCDS CCDS8584.1 |
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.
Products for CLEC4C gene
Catalog | Product Name | Application | Company |
GFS:E02906 | C-type lectin domain family 4, member C; ELISA kit | ELISA | n/a |
GFS:A02906 | C-type lectin domain family 4, member C; Anti | ANTIBODIES | n/a |
GFS:P02906 | C-type lectin domain family 4, member C; Protien | Protien | n/a |