Symbol: Name: ID: |
ATG4C ATG4 autophagy related 4 homolog C (S. cerevisiae) GFS:5168 |
Gene name: | ATG4C |
Chromosome: | 1p31.3 |
Previous Symbols: | AUTL1, APG4C |
Previous Names: | AUT (S. cerevisiae)-like 1, cysteine endopeptidase; AUT-like 1, cysteine endopeptidase (S. cerevisiae), "APG4 autophagy 4 homolog C (S. cerevisiae)" |
Aliases: | FLJ14867, AUTL3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2651854 | Rat Genome Database ID: | RGD:1598323 |
HGNC ID: | HGNC:16040 | RefSeq IDs: | NM_032852 |
Entrez Gene ID: | 84938 | Ensembl Gene ID: | ENSG00000125703 |
VEGA IDs: | OTTHUMG00000009142 | UniProt ID: | Q96DT6 |
UCSC ID: | uc001dau.2 | OMIM ID: | 611339 |
Pubmed: | PMID12446702 | ||
CCDS IDs: | CCDSCCDS623.1 |
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008].
Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Products for ATG4C gene
Catalog | Product Name | Application | Company |
GFS:E05168 | ATG4 autophagy related 4 homolog C (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A05168 | ATG4 autophagy related 4 homolog C (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P05168 | ATG4 autophagy related 4 homolog C (S. cerevisiae); Protien | Protien | n/a |