Symbol: Name: ID: |
ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae) GFS:5596 |
Gene name: | ATG4A |
Chromosome: | Xq22.1-q22.3 |
Previous Symbols: | AUTL2, APG4A |
Previous Names: | AUT-like 2, cysteine endopeptidase (S. cerevisiae), "APG4 autophagy 4 homolog A (S. cerevisiae)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2147903 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16489 | RefSeq IDs: | NM_052936 |
Entrez Gene ID: | 115201 | Ensembl Gene ID: | ENSG00000101844 |
VEGA IDs: | OTTHUMG00000022176 | UniProt ID: | Q8WYN0 |
UCSC ID: | uc004enr.2 | OMIM ID: | 300663 |
Pubmed: | PMID12446702 PMID 12473658 | ||
CCDS IDs: | CCDSCCDS14538.1 CCDS CCDS14539.1 |
Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.
Products for ATG4A gene
Catalog | Product Name | Application | Company |
GFS:E05596 | ATG4 autophagy related 4 homolog A (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A05596 | ATG4 autophagy related 4 homolog A (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P05596 | ATG4 autophagy related 4 homolog A (S. cerevisiae); Protien | Protien | n/a |