Symbol: Name: ID: |
VAV3 vav 3 guanine nucleotide exchange factor GFS:2438 |
Gene name: | VAV3 |
Chromosome: | 1p13.3 |
Previous Symbols: | |
Previous Names: | vav 3 oncogene |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1888518 | Rat Genome Database ID: | RGD:1565941 |
HGNC ID: | HGNC:12659 | RefSeq IDs: | NM_001079874 |
Entrez Gene ID: | 10451 | Ensembl Gene ID: | ENSG00000134215 |
VEGA IDs: | OTTHUMG00000010995 | UniProt ID: | Q9UKW4 |
UCSC ID: | uc001dvk.1 | OMIM ID: | 605541 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS785.1 CCDS CCDS44181.1 |
Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Products for VAV3 gene
Catalog | Product Name | Application | Company |
GFS:E02438 | vav 3 guanine nucleotide exchange factor; ELISA kit | ELISA | n/a |
GFS:A02438 | vav 3 guanine nucleotide exchange factor; Anti | ANTIBODIES | n/a |
GFS:P02438 | vav 3 guanine nucleotide exchange factor; Protien | Protien | n/a |