Symbol: Name: ID: |
VAV1 vav 1 guanine nucleotide exchange factor GFS:2436 |
Gene name: | VAV1 |
Chromosome: | 19p13.2 |
Previous Symbols: | VAV |
Previous Names: | vav 1 oncogene |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98923 | Rat Genome Database ID: | RGD:3951 |
HGNC ID: | HGNC:12657 | RefSeq IDs: | NM_005428 |
Entrez Gene ID: | 7409 | Ensembl Gene ID: | ENSG00000141968 |
VEGA IDs: | UniProt ID: | P15498 | |
UCSC ID: | uc002mfu.1 | OMIM ID: | 164875 |
Pubmed: | PMID9438848 | ||
CCDS IDs: | CCDSCCDS12174.1 |
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Products for VAV1 gene
Catalog | Product Name | Application | Company |
GFS:E02436 | vav 1 guanine nucleotide exchange factor; ELISA kit | ELISA | n/a |
GFS:A02436 | vav 1 guanine nucleotide exchange factor; Anti | ANTIBODIES | n/a |
GFS:P02436 | vav 1 guanine nucleotide exchange factor; Protien | Protien | n/a |