Symbol: Name: ID: |
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 GFS:1711 |
Gene name: | TNFAIP3 |
Chromosome: | 6q23-q25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | A20, OTUD7C |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1196377 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11896 | RefSeq IDs: | NM_006290 |
Entrez Gene ID: | 7128 | Ensembl Gene ID: | ENSG00000118503 |
VEGA IDs: | OTTHUMG00000015664 | UniProt ID: | P21580 |
UCSC ID: | uc003qhr.2 | OMIM ID: | 191163 |
Pubmed: | PMID2118515 | ||
CCDS IDs: | CCDSCCDS5187.1 |
Tumor necrosis factor, alpha-induced protein 3 is a protein that in humans is encoded by the TNFAIP3 gene. This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.
Products for TNFAIP3 gene
Catalog | Product Name | Application | Company |
GFS:E01711 | tumor necrosis factor, alpha-induced protein 3; ELISA kit | ELISA | n/a |
GFS:A01711 | tumor necrosis factor, alpha-induced protein 3; Anti | ANTIBODIES | n/a |
GFS:P01711 | tumor necrosis factor, alpha-induced protein 3; Protien | Protien | n/a |