Symbol: Name: ID: |
TNNI3 troponin I type 3 (cardiac) GFS:1758 |
Gene name: | TNNI3 |
Chromosome: | 19q13.4 |
Previous Symbols: | |
Previous Names: | troponin I, cardiac |
Aliases: | TNNC1, CMH7 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98783 | Rat Genome Database ID: | RGD:62052 |
HGNC ID: | HGNC:11947 | RefSeq IDs: | NM_000363 |
Entrez Gene ID: | 7137 | Ensembl Gene ID: | ENSG00000129991 |
VEGA IDs: | UniProt ID: | P19429 | |
UCSC ID: | uc010yft.1 | OMIM ID: | 191044 |
Pubmed: | PMID9605869 PMID 9241277 | ||
CCDS IDs: | CCDSCCDS42628.1 |
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Products for TNNI3 gene
Catalog | Product Name | Application | Company |
GFS:E01758 | troponin I type 3 (cardiac); ELISA kit | ELISA | n/a |
GFS:A01758 | troponin I type 3 (cardiac); Anti | ANTIBODIES | n/a |
GFS:P01758 | troponin I type 3 (cardiac); Protien | Protien | n/a |