Symbol: Name: ID: |
TNNI1 troponin I type 1 (skeletal, slow) GFS:1756 |
Gene name: | TNNI1 |
Chromosome: | 1q31.3 |
Previous Symbols: | |
Previous Names: | troponin I, skeletal, slow |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105073 | Rat Genome Database ID: | RGD:621765 |
HGNC ID: | HGNC:11945 | RefSeq IDs: | NM_003281 |
Entrez Gene ID: | 7135 | Ensembl Gene ID: | ENSG00000159173 |
VEGA IDs: | OTTHUMG00000035736 | UniProt ID: | P19237 |
UCSC ID: | uc010ppq.1 | OMIM ID: | 191042 |
Pubmed: | PMID2365354 PMID 8144655 | ||
CCDS IDs: | CCDSCCDS1411.1 |
Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for TNNI1 gene
Catalog | Product Name | Application | Company |
GFS:E01756 | troponin I type 1 (skeletal, slow); ELISA kit | ELISA | n/a |
GFS:A01756 | troponin I type 1 (skeletal, slow); Anti | ANTIBODIES | n/a |
GFS:P01756 | troponin I type 1 (skeletal, slow); Protien | Protien | n/a |