Symbol: Name: ID: |
TNNI2 troponin I type 2 (skeletal, fast) GFS:1757 |
Gene name: | TNNI2 |
Chromosome: | 11p15.5 |
Previous Symbols: | |
Previous Names: | troponin I, skeletal, fast |
Aliases: | AMCD2B, DA2B, FSSV |
Name Aliases: | troponin I, fast-twitch skeletal muscle isoform, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105070 | Rat Genome Database ID: | RGD:62050 |
HGNC ID: | HGNC:11946 | RefSeq IDs: | NM_003282 |
Entrez Gene ID: | 7136 | Ensembl Gene ID: | ENSG00000130598 |
VEGA IDs: | OTTHUMG00000012253 | UniProt ID: | P48788 |
UCSC ID: | uc010qxe.1 | OMIM ID: | 191043 |
Pubmed: | PMID9016781 | ||
CCDS IDs: | CCDSCCDS31333.1 |
Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene. This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Products for TNNI2 gene
Catalog | Product Name | Application | Company |
GFS:E01757 | troponin I type 2 (skeletal, fast); ELISA kit | ELISA | n/a |
GFS:A01757 | troponin I type 2 (skeletal, fast); Anti | ANTIBODIES | n/a |
GFS:P01757 | troponin I type 2 (skeletal, fast); Protien | Protien | n/a |