Symbol: Name: ID: |
TRIM63 tripartite motif containing 63 GFS:5138 |
Gene name: | TRIM63 |
Chromosome: | 1p34-p33 |
Previous Symbols: | RNF28 |
Previous Names: | ring finger protein 28, "tripartite motif-containing 63" |
Aliases: | MURF-1, IRF, SMRZ |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2447992 | Rat Genome Database ID: | RGD:619964 |
HGNC ID: | HGNC:16007 | RefSeq IDs: | NM_032588 |
Entrez Gene ID: | 84676 | Ensembl Gene ID: | ENSG00000158022 |
VEGA IDs: | OTTHUMG00000007510 | UniProt ID: | Q969Q1 |
UCSC ID: | uc001bli.1 | OMIM ID: | 606131 |
Pubmed: | PMID11243782 PMID 11283016 | ||
CCDS IDs: | CCDSCCDS273.1 |
E3 ubiquitin-protein ligase TRIM63 is an enzyme that in humans is encoded by the TRIM63 gene.
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Products for TRIM63 gene
Catalog | Product Name | Application | Company |
GFS:E05138 | tripartite motif containing 63; ELISA kit | ELISA | n/a |
GFS:A05138 | tripartite motif containing 63; Anti | ANTIBODIES | n/a |
GFS:P05138 | tripartite motif containing 63; Protien | Protien | n/a |