Symbol: Name: ID: |
TRIM24 tripartite motif containing 24 GFS:1628 |
Gene name: | TRIM24 |
Chromosome: | 7q32-q34 |
Previous Symbols: | TIF1 |
Previous Names: | transcriptional intermediary factor 1, "tripartite motif-containing 24" |
Aliases: | hTIF1, Tif1a, RNF82 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109275 | Rat Genome Database ID: | RGD:1560596 |
HGNC ID: | HGNC:11812 | RefSeq IDs: | NM_003852 |
Entrez Gene ID: | 8805 | Ensembl Gene ID: | ENSG00000122779 |
VEGA IDs: | OTTHUMG00000155820 | UniProt ID: | O15164 |
UCSC ID: | uc003vuc.2 | OMIM ID: | 603406 |
Pubmed: | PMID9115274 PMID 9191165 | ||
CCDS IDs: | CCDSCCDS5847.1 CCDS CCDS47720.1 |
Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Products for TRIM24 gene
Catalog | Product Name | Application | Company |
GFS:E01628 | tripartite motif containing 24; ELISA kit | ELISA | n/a |
GFS:A01628 | tripartite motif containing 24; Anti | ANTIBODIES | n/a |
GFS:P01628 | tripartite motif containing 24; Protien | Protien | n/a |