Symbol: Name: ID: |
TRIM5 tripartite motif containing 5 GFS:5403 |
Gene name: | TRIM5 |
Chromosome: | 11p15 |
Previous Symbols: | |
Previous Names: | tripartite motif-containing 5 |
Aliases: | RNF88, TRIM5alpha |
Name Aliases: | tripartite motif protein TRIM5, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3646853 | Rat Genome Database ID: | RGD:1304579 |
HGNC ID: | HGNC:16276 | RefSeq IDs: | NM_033034 |
Entrez Gene ID: | 85363 | Ensembl Gene ID: | ENSG00000132256 |
VEGA IDs: | OTTHUMG00000066893 | UniProt ID: | Q9C035 |
UCSC ID: | uc001mbm.1 | OMIM ID: | 608487 |
Pubmed: | PMID11331580 | ||
CCDS IDs: | CCDSCCDS31392.1 CCDS CCDS31393.1 CCDS CCDS31394.1 |
Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene. The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009].
Function: Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity
Products for TRIM5 gene
Catalog | Product Name | Application | Company |
GFS:E05403 | tripartite motif containing 5; ELISA kit | ELISA | n/a |
GFS:A05403 | tripartite motif containing 5; Anti | ANTIBODIES | n/a |
GFS:P05403 | tripartite motif containing 5; Protien | Protien | n/a |