Symbol: Name: ID: |
TRIM33 tripartite motif containing 33 GFS:5416 |
Gene name: | TRIM33 |
Chromosome: | 1p13.1 |
Previous Symbols: | |
Previous Names: | tripartite motif-containing 33 |
Aliases: | TIF1GAMMA, FLJ11429, KIAA1113, TIFGAMMA, RFG7, TF1G, TIF1G, PTC7 |
Name Aliases: | transcriptional intermediary factor 1 gamma, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2137357 | Rat Genome Database ID: | RGD:1307339 |
HGNC ID: | HGNC:16290 | RefSeq IDs: | NM_015906 |
Entrez Gene ID: | 51592 | Ensembl Gene ID: | ENSG00000197323 |
VEGA IDs: | OTTHUMG00000011891 | UniProt ID: | Q9UPN9 |
UCSC ID: | uc001eew.2 | OMIM ID: | 605769 |
Pubmed: | PMID11331580 PMID 10022127 | ||
CCDS IDs: | CCDSCCDS872.1 CCDS CCDS873.1 |
Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].
Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Products for TRIM33 gene
Catalog | Product Name | Application | Company |
GFS:E05416 | tripartite motif containing 33; ELISA kit | ELISA | n/a |
GFS:A05416 | tripartite motif containing 33; Anti | ANTIBODIES | n/a |
GFS:P05416 | tripartite motif containing 33; Protien | Protien | n/a |