Symbol: Name: ID: |
TRIM32 tripartite motif containing 32 GFS:5497 |
Gene name: | TRIM32 |
Chromosome: | 9q33.1 |
Previous Symbols: | LGMD2H |
Previous Names: | limb girdle muscular dystrophy 2H (autosomal recessive), "tripartite motif-containing 32" |
Aliases: | HT2A, TATIP, BBS11 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917057 | Rat Genome Database ID: | RGD:1305238 |
HGNC ID: | HGNC:16380 | RefSeq IDs: | NM_001099679 |
Entrez Gene ID: | 22954 | Ensembl Gene ID: | ENSG00000119401 |
VEGA IDs: | OTTHUMG00000021026 | UniProt ID: | Q13049 |
UCSC ID: | uc004bjw.2 | OMIM ID: | 602290 |
Pubmed: | PMID11331580 PMID 7778269 PMID 16606853 | ||
CCDS IDs: | CCDSCCDS6817.1 |
Tripartite motif-containing protein 32 is a protein that in humans is encoded by the TRIM32 gene. Since its discovery in 1995, TRIM32 has been shown to be implicated in a number of diverse biological pathways.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008].
Function: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
Products for TRIM32 gene
Catalog | Product Name | Application | Company |
GFS:E05497 | tripartite motif containing 32; ELISA kit | ELISA | n/a |
GFS:A05497 | tripartite motif containing 32; Anti | ANTIBODIES | n/a |
GFS:P05497 | tripartite motif containing 32; Protien | Protien | n/a |