Symbol: Name: ID: |
TRIM28 tripartite motif containing 28 GFS:5499 |
Gene name: | TRIM28 |
Chromosome: | 19q13.4 |
Previous Symbols: | |
Previous Names: | tripartite motif-containing 28 |
Aliases: | TIF1B, KAP1, TF1B, RNF96 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109274 | Rat Genome Database ID: | RGD:620289 |
HGNC ID: | HGNC:16384 | RefSeq IDs: | NM_005762 |
Entrez Gene ID: | 10155 | Ensembl Gene ID: | ENSG00000130726 |
VEGA IDs: | UniProt ID: | Q13263 | |
UCSC ID: | uc002qtg.1 | OMIM ID: | 601742 |
Pubmed: | PMID11331580 PMID 11226167 | ||
CCDS IDs: | CCDSCCDS12985.1 |
Tripartite motif-containing 28 (TRIM28) also known as transcriptional intermediary factor 1β (TIF1β) is a protein that in humans is encoded by the TRIM24 gene.
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.
Products for TRIM28 gene
Catalog | Product Name | Application | Company |
GFS:E05499 | tripartite motif containing 28; ELISA kit | ELISA | n/a |
GFS:A05499 | tripartite motif containing 28; Anti | ANTIBODIES | n/a |
GFS:P05499 | tripartite motif containing 28; Protien | Protien | n/a |