Symbol: Name: ID: |
TRIM22 tripartite motif containing 22 GFS:5495 |
Gene name: | TRIM22 |
Chromosome: | 11p15 |
Previous Symbols: | |
Previous Names: | tripartite motif-containing 22 |
Aliases: | STAF50, GPSTAF50, RNF94 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:16379 | RefSeq IDs: | NM_001199573 |
Entrez Gene ID: | 10346 | Ensembl Gene ID: | ENSG00000132274 |
VEGA IDs: | OTTHUMG00000066904 | UniProt ID: | Q8IYM9 |
UCSC ID: | uc001mbr.2 | OMIM ID: | 606559 |
Pubmed: | PMID11331580 PMID 11096452 | ||
CCDS IDs: | CCDSCCDS41612.1 |
Tripartite motif-containing 22, also known as TRIM22, is a protein which in humans is encoded by the TRIM22 gene.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Function: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Products for TRIM22 gene
Catalog | Product Name | Application | Company |
GFS:E05495 | tripartite motif containing 22; ELISA kit | ELISA | n/a |
GFS:A05495 | tripartite motif containing 22; Anti | ANTIBODIES | n/a |
GFS:P05495 | tripartite motif containing 22; Protien | Protien | n/a |