Symbol: Name: ID: |
TRIM11 tripartite motif containing 11 GFS:5408 |
Gene name: | TRIM11 |
Chromosome: | 1q42.13 |
Previous Symbols: | |
Previous Names: | tripartite motif-containing 11 |
Aliases: | RNF92, BIA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2137355 | Rat Genome Database ID: | RGD:1305448 |
HGNC ID: | HGNC:16281 | RefSeq IDs: | NM_145214 |
Entrez Gene ID: | 81559 | Ensembl Gene ID: | ENSG00000154370 |
VEGA IDs: | OTTHUMG00000039773 | UniProt ID: | Q96F44 |
UCSC ID: | uc001hss.2 | OMIM ID: | 607868 |
Pubmed: | PMID11331580 | ||
CCDS IDs: | CCDSCCDS31048.1 |
Tripartite motif-containing protein 11 is a protein that in humans is encoded by the TRIM11 gene.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008].
Function: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Products for TRIM11 gene
Catalog | Product Name | Application | Company |
GFS:E05408 | tripartite motif containing 11; ELISA kit | ELISA | n/a |
GFS:A05408 | tripartite motif containing 11; Anti | ANTIBODIES | n/a |
GFS:P05408 | tripartite motif containing 11; Protien | Protien | n/a |