Symbol: Name: ID: |
TMPRSS3 transmembrane protease, serine 3 GFS:1693 |
Gene name: | TMPRSS3 |
Chromosome: | 21q22.3 |
Previous Symbols: | DFNB10, DFNB8 |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2155445 | Rat Genome Database ID: | RGD:1310135 |
HGNC ID: | HGNC:11877 | RefSeq IDs: | NM_024022 |
Entrez Gene ID: | 64699 | Ensembl Gene ID: | ENSG00000160183 |
VEGA IDs: | OTTHUMG00000086796 | UniProt ID: | P57727 |
UCSC ID: | uc002zbb.2 | OMIM ID: | 605511 |
Pubmed: | PMID11462234 PMID 11907649 | ||
CCDS IDs: | CCDSCCDS13686.1 CCDS CCDS42939.1 |
Transmembrane protease, serine 3 is an enzyme that in humans is encoded by the TMPRSS3 gene. This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq].
Function: Probable protease. Seems to be capable of activating ENaC.
Products for TMPRSS3 gene
Catalog | Product Name | Application | Company |
GFS:E01693 | transmembrane protease, serine 3; ELISA kit | ELISA | n/a |
GFS:A01693 | transmembrane protease, serine 3; Anti | ANTIBODIES | n/a |
GFS:P01693 | transmembrane protease, serine 3; Protien | Protien | n/a |