Symbol: Name: ID: |
TMPRSS2 transmembrane protease, serine 2 GFS:1692 |
Gene name: | TMPRSS2 |
Chromosome: | 21q22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PRSS10 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354381 | Rat Genome Database ID: | RGD:620766 |
HGNC ID: | HGNC:11876 | RefSeq IDs: | NM_001135099 |
Entrez Gene ID: | 7113 | Ensembl Gene ID: | ENSG00000184012 |
VEGA IDs: | OTTHUMG00000086762 | UniProt ID: | O15393 |
UCSC ID: | uc010gor.2 | OMIM ID: | 602060 |
Pubmed: | PMID9325052 | ||
CCDS IDs: | CCDSCCDS33564.1 |
Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Products for TMPRSS2 gene
Catalog | Product Name | Application | Company |
GFS:E01692 | transmembrane protease, serine 2; ELISA kit | ELISA | n/a |
GFS:A01692 | transmembrane protease, serine 2; Anti | ANTIBODIES | n/a |
GFS:P01692 | transmembrane protease, serine 2; Protien | Protien | n/a |