Symbol: Name: ID: |
TRPV6 transient receptor potential cation channel, subfamily V, member 6 GFS:3441 |
Gene name: | TRPV6 |
Chromosome: | 7q34 |
Previous Symbols: | ECAC2 |
Previous Names: | epithelial calcium channel 2 |
Aliases: | CaT1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927259 | Rat Genome Database ID: | RGD:69335 |
HGNC ID: | HGNC:14006 | RefSeq IDs: | NM_018646 |
Entrez Gene ID: | 55503 | Ensembl Gene ID: | ENSG00000165125 |
VEGA IDs: | OTTHUMG00000157158 | UniProt ID: | Q9H1D0 |
UCSC ID: | uc003wbx.1 | OMIM ID: | 606680 |
Pubmed: | PMID11097838 PMID 11549322 PMID 16382100 PMID 16717058 | ||
CCDS IDs: | CCDSCCDS5874.1 |
Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH; MIM 168450), or calcitonin (CALCA; MIM 114130).[supplied by OMIM, Feb 2005]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)
Products for TRPV6 gene
Catalog | Product Name | Application | Company |
GFS:E03441 | transient receptor potential cation channel, subfamily V, member 6; ELISA kit | ELISA | n/a |
GFS:A03441 | transient receptor potential cation channel, subfamily V, member 6; Anti | ANTIBODIES | n/a |
GFS:P03441 | transient receptor potential cation channel, subfamily V, member 6; Protien | Protien | n/a |