Symbol: Name: ID: |
TRPV4 transient receptor potential cation channel, subfamily V, member 4 GFS:6973 |
Gene name: | TRPV4 |
Chromosome: | 12q24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | OTRPC4, TRP12, VROAC, VRL-2, VR-OAC, CMT2C |
Name Aliases: | osmosensitive transient receptor potential channel 4 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926945 | Rat Genome Database ID: | RGD:69337 |
HGNC ID: | HGNC:18083 | RefSeq IDs: | NM_001177428 |
Entrez Gene ID: | 59341 | Ensembl Gene ID: | ENSG00000111199 |
VEGA IDs: | UniProt ID: | Q9HBA0 | |
UCSC ID: | uc001tpk.1 | OMIM ID: | 605427 |
Pubmed: | PMID11025659 PMID 11081638 PMID 16382100 PMID 20037587 | ||
CCDS IDs: | CCDSCCDS9134.1 CCDS CCDS9135.1 |
Transient receptor potential cation channel subfamily V member 4 is a protein that in humans is encoded by the TRPV4 gene.
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010].
Function: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
Products for TRPV4 gene
Catalog | Product Name | Application | Company |
GFS:E06973 | transient receptor potential cation channel, subfamily V, member 4; ELISA kit | ELISA | n/a |
GFS:A06973 | transient receptor potential cation channel, subfamily V, member 4; Anti | ANTIBODIES | n/a |
GFS:P06973 | transient receptor potential cation channel, subfamily V, member 4; Protien | Protien | n/a |