Symbol: Name: ID: |
TRPC6 transient receptor potential cation channel, subfamily C, member 6 GFS:2150 |
Gene name: | TRPC6 |
Chromosome: | 11q22.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TRP6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109523 | Rat Genome Database ID: | RGD:619788 |
HGNC ID: | HGNC:12338 | RefSeq IDs: | NM_004621 |
Entrez Gene ID: | 7225 | Ensembl Gene ID: | ENSG00000137672 |
VEGA IDs: | UniProt ID: | Q9Y210 | |
UCSC ID: | uc001pgk.3 | OMIM ID: | 603652 |
Pubmed: | PMID9925922 PMID 16382100 | ||
CCDS IDs: | CCDSCCDS8311.1 |
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS). The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Products for TRPC6 gene
Catalog | Product Name | Application | Company |
GFS:E02150 | transient receptor potential cation channel, subfamily C, member 6; ELISA kit | ELISA | n/a |
GFS:A02150 | transient receptor potential cation channel, subfamily C, member 6; Anti | ANTIBODIES | n/a |
GFS:P02150 | transient receptor potential cation channel, subfamily C, member 6; Protien | Protien | n/a |